Neurological mouse mutants and the genes of myelin

Nave, K.-A.

doi:10.1002/jnr.490380602

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Neurological mouse mutants and the genes of myelin

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Nave, K.-A.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Nave, K.-A. (1994). Neurological mouse mutants and the genes of myelin. Journal of Neuroscience Research, 38(6), 607-612. doi:10.1002/jnr.490380602.

Cite as: https://hdl.handle.net/21.11116/0000-000D-2C12-E

Abstract

The prospect to create mouse mutants of virtually any cloned gene has renewed interest in the genetic analysis of mammalian brain development. A diverse group of spontaneous and engineered mouse mutants, characterized by a defect of myelin formation, has been intensively studied from the morphological to the molecular level. In this system, genetics has been successfully applied to analyze a corresponding set of membrane proteins which help to elaborate a defined structural entity, compact myelin. Shiverer, jimpy, Trembler, and protein zero (P0)-deficient mice demonstrate the overall function of myelination and have become models for human neurological diseases. They also illustrate some of the problems encountered in defining protein functions from complex mutant phenotypes.