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Journal Article

Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

MPS-Authors
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Harbauer,  Angelika B.
Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society;

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Hees,  Jara Tabitha
IMPRS-BI: Martinsried, MPI of Neurobiology, Max Planck Society;
IMPRS-LS: Martinsried, MPI of Neurobiology, Max Planck Society;
Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society;

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Wanderoy,  Simone
Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society;

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Segura,  Inmaculada
Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society;

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Citation

Harbauer, A. B., Hees, J. T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., et al. (2022). Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron, 110(9), 1516-1531.e9. doi:10.1016/j.neuron.2022.01.035.


Cite as: https://hdl.handle.net/21.11116/0000-000D-2B87-B
Abstract
PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translation is required for this mitophagy pathway to be active far from the soma. The Pink1 transcript is associated and cotransported with neuronal mitochondria. In concert with translation, the mitochondrial outer membrane proteins synaptojanin 2 binding protein (SYNJ2BP) and synaptojanin 2 (SYNJ2) are required for tethering Pink1 mRNA to mitochondria via an RNA-binding domain in SYNJ2. This neuron-specific adaptation for the local translation of PINK1 provides distal mitochondria with a continuous supply of PINK1 for the activation of mitophagy.