An ancient control of epithelial barrier formation and wound healing

Moussian, B; Uv, AE

doi:10.1002/bies.20308

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

An ancient control of epithelial barrier formation and wound healing

MPS-Authors

/persons/resource/persons214650

Moussian, B
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Moussian, B., & Uv, A. (2005). An ancient control of epithelial barrier formation and wound healing. Bioessays, 27(10), 987-990. doi:10.1002/bies.20308.

Cite as: https://hdl.handle.net/21.11116/0000-000D-2F9F-D

Abstract

Animal epithelia are lined with apical surface matrices, which protect against pathogens, dehydration and physical damage of the underlying cells. The proteins and polysaccharides that comprise these protective barriers vary greatly within the animal kingdom and have evolved in response to the biological needs of various organisms. Yet the genetic control of barrier formation and its regeneration upon wounding appears conserved between vertebrates and insects that are evolutionary more than several hundred millions of years apart. A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans.