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Journal Article

Cell-type-specific propagation of visual flicker

MPS-Authors

Schneider,  Marius
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Tzanou,  Athanasia
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

Uran,  Cem
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

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Vinck,  Martin       
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;
Vinck Lab, Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S221112472300503X
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Citation

Schneider, M., Tzanou, A., Uran, C., & Vinck, M. (2023). Cell-type-specific propagation of visual flicker. Cell Reports, 42(5): 112492. doi:10.1016/j.celrep.2023.112492.


Cite as: https://hdl.handle.net/21.11116/0000-000D-352C-7
Abstract
Rhythmic flicker stimulation has gained interest as a treatment for neurodegenerative diseases and as a method for frequency tagging neural activity. Yet, little is known about the way in which flicker-induced synchronization propagates across cortical levels and impacts different cell types. Here, we use Neuropixels to record from the lateral geniculate nucleus (LGN), the primary visual cortex (V1), and CA1 in mice while presenting visual flicker stimuli. LGN neurons show strong phase locking up to 40 Hz, whereas phase locking is substantially weaker in V1 and is absent in CA1. Laminar analyses reveal an attenuation of phase locking at 40 Hz for each processing stage. Gamma-rhythmic flicker predominantly entrains fast-spiking interneurons. Optotagging experiments show that these neurons correspond to either parvalbumin (PV+) or narrow-waveform somatostatin (Sst+) neurons. A computational model can explain the observed differences based on the neurons’ capacitative low-pass filtering properties. In summary, the propagation of synchronized activity and its effect on distinct cell types strongly depend on its frequency.