Functional connectivity to entorhinal cortex in hypertensive Alzheimer’s 
disease rat models

Chen, Y; Fernandez, Z; Scheel, N; Gifani, M; Qian, C; Dorrance, AM; Counts, SE; Zhu, DC

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Functional connectivity to entorhinal cortex in hypertensive Alzheimer’s disease rat models

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Chen, Y
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://submissions.mirasmart.com/ISMRM2023/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-141
(Abstract)

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Citation

Chen, Y., Fernandez, Z., Scheel, N., Gifani, M., Qian, C., Dorrance, A., et al. (2023). Functional connectivity to entorhinal cortex in hypertensive Alzheimer’s disease rat models. Poster presented at 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023), Toronto, Canada.

Cite as: https://hdl.handle.net/21.11116/0000-000D-35A2-0

Abstract

Extensive studies have revealed that the entorhinal cortex (EC) plays a critical role in Alzheimer’s disease (AD) development. However, EC functional connectivity and its associated network abnormalities are understudied, especially in rodent models. To the best of our knowledge, this is the first study to report disrupted EC functional connectivity in hypertensive AD rodents using resting-state fMRI. Our results may provide new insights into the impaired EC connectivity patterns and enable the search for novel preclinical EC-based fMRI biomarkers for AD studies. In addition, our novel animal model provides new information to understand the link between hypertension and AD.