Prospective frequency correction with metabolite cycling for improved spectral 
quality in the prefrontal cortex at 7T

Chan, KL; Dimitrov, IE; Trivedi, MH; Henning, A

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Prospective frequency correction with metabolite cycling for improved spectral quality in the prefrontal cortex at 7T

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Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://submissions.mirasmart.com/ISMRM2023/Itinerary/ConferenceMatrixEventDetail.aspx?id=161
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Citation

Chan, K., Dimitrov, I., Trivedi, M., & Henning, A. (2023). Prospective frequency correction with metabolite cycling for improved spectral quality in the prefrontal cortex at 7T. In 2023 ISMRM & ISMRT Annual Meeting & Exhibition (ISMRM 2023).

Cite as: https://hdl.handle.net/21.11116/0000-000D-3828-8

Abstract

The prefrontal cortex plays a central role in controlling executive functions such as decision-making and emotional-monitoring and has thus been the subject of several 1H-MRS studies on psychiatric illnesses. This region, however, is sensitive to motion-induced increases in linewidths due to the voxel moving away from the originally shimmed location. Here, we combined metabolite cycling (MC) with continuous prospective frequency correction to better account for frequency instabilities when performing single-voxel brain MRS at 7T. We find that MC sLASER with continuous prospective frequency correction reduces frequency instability, water linewidths, and N-acetylaspartate linewidths relative to semi-LASER acquisitions without prospective frequency correction.