Models for the generation of the embryonic body axes: ontogenetic and 
evolutionary aspects

Meinhardt, H

doi:10.1016/j.gde.2004.06.012

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Models for the generation of the embryonic body axes: ontogenetic and evolutionary aspects

MPS-Authors

/persons/resource/persons273992

Meinhardt, H
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Meinhardt, H. (2004). Models for the generation of the embryonic body axes: ontogenetic and evolutionary aspects. Opinion in Genetics & Development, 14(4), 446-454. doi:10.1016/j.gde.2004.06.012.

Cite as: https://hdl.handle.net/21.11116/0000-000D-3BB9-1

Abstract

Coelenterates including hydra are assumed to be close to the last common ancestor before bilaterality evolved. Models based on local self-enhancement and long-range inhibition account for pattern formation and regeneration along this ancestral axis. The body of a hydra-like ancestor evolved into the brain and heart of higher organisms, accounting for the close relationship of both patterning processes. Bilateria require a long-extended organizing region to pattern their dorsoventral axis. Models reveal the difficulties in the generation of such a stripe-like organizer and account for different mechanisms realized in vertebrates and insects. Common pathways involved in hydra budding and in the formation of appendages in higher organisms suggest a possible link.