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Journal Article

Towing of sensory axons by their migrating target cells in vivo

MPS-Authors
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Gilmour,  D       
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Knaut,  H       
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Maischein,  H-M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Nüsslein-Volhard,  C       
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Gilmour, D., Knaut, H., Maischein, H.-M., & Nüsslein-Volhard, C. (2004). Towing of sensory axons by their migrating target cells in vivo. Nature Neuroscience, 7(5), 491-492. doi:10.1038/nn1235.


Cite as: https://hdl.handle.net/21.11116/0000-000D-3BC2-6
Abstract
Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.