Migration and Function of a Glial Subtype in the Vertebrate Peripheral Nervous 
System

Gilmour, D; Maischein, H-M; Nüsslein-Volhard, C

doi:10.1016/s0896-6273(02)00683-9

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Migration and Function of a Glial Subtype in the Vertebrate Peripheral Nervous System

MPS-Authors

/persons/resource/persons285532

Gilmour, D
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons224247

Maischein, H-M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271460

Nüsslein-Volhard, C
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Gilmour, D., Maischein, H.-M., & Nüsslein-Volhard, C. (2002). Migration and Function of a Glial Subtype in the Vertebrate Peripheral Nervous System. Neuron, 34(4), 577-588. doi:10.1016/s0896-6273(02)00683-9.

引用: https://hdl.handle.net/21.11116/0000-000D-3BCD-B

要旨

Glia-axon interactions are essential for the development and function of the nervous system. We combine in vivo imaging and genetics to address the mechanism by which the migration of these cells is coordinated during embryonic development. Using stable transgenic lines, we have followed the migration of one subset of glial cells and their target axons in living zebrafish embryos. These cells coalesce at an early stage and remain coupled throughout migration, with axons apparently pathfinding for glia. Mutant analysis demonstrates that axons provide instructive cues that are sufficient to control glial guidance. Furthermore, mutations in the transcription factor Sox10/cls uncouple the migration of axons and glia. Finally, genetic ablation of this glial subtype reveals an essential role in nerve fasciculation.