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Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders

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Yusupov,  Natan
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Dieckmann,  Linda
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Erhart,  Mira
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Sauer,  Susann
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Rex-Haffner,  Monika
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Kopf-Beck,  Johannes
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Brueckl,  Tanja M.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Czamara,  Darina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Binder,  Elisabeth B.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Yusupov, N., Dieckmann, L., Erhart, M., Sauer, S., Rex-Haffner, M., Kopf-Beck, J., et al. (2023). Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders. NEUROPSYCHOPHARMACOLOGY. doi:10.1038/s41386-023-01579-3.


Cite as: https://hdl.handle.net/21.11116/0000-000D-3D52-3
Abstract
Different psychiatric disorders as well as exposure to adverse life events have individually been associated with multiple age-related diseases and mortality. Age acceleration in different epigenetic clocks can serve as biomarker for such risk and could help to disentangle the interplay of psychiatric comorbidity and early adversity on age-related diseases and mortality. We evaluated five epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge and DunedinPoAm) in a transdiagnostic psychiatric sample using epigenome-wide DNA methylation data from peripheral blood of 429 subjects from two studies at the Max Planck Institute of Psychiatry. Burden of psychiatric disease, represented by a weighted score, was significantly associated with biological age acceleration as measured by GrimAge and DunedinPoAm (R2-adj. 0.22 and 0.33 for GrimAge and DunedinPoAm, respectively), but not the other investigated clocks. The relation of burden of psychiatric disease appeared independent of differences in socioeconomic status and medication. Our findings indicate that increased burden of psychiatric disease may associate with accelerated biological aging. This highlights the importance of medical management of patients with multiple psychiatric comorbidities and the potential usefulness of specific epigenetic clocks for early detection of risk and targeted intervention to reduce mortality in psychiatric patients.