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Journal Article

Maturation of amyloid β fibrils alters their molecular stability

MPS-Authors
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Becker,  Stefan
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Giller,  Karin
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Sieme,  Daniel
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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d3cp01276j.pdf
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Citation

Becker, S., Giller, K., Sieme, D., & Rezaei-Ghaleh, N. (2023). Maturation of amyloid β fibrils alters their molecular stability. Physical Chemistry Chemical Physics, 25, 15099-15103. doi:10.1039/d3cp01276j.


Cite as: https://hdl.handle.net/21.11116/0000-000D-5472-4
Abstract
Little is known about how maturation of Alzheimer's disease-related amyloid β (Aβ) fibrils alters their stability and potentially influences their spreading in the brain. Using high-pressure NMR, we show that progression from early to late Aβ40 aggregates enhances the kinetic stability, while ageing during weeks to months enhances their thermodynamic stability.