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How much of the response to selection can be attributed to discrete genes?

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Chan,  F       
Chan Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Barton, N., Belohlavy, S., Sachdeva, H., & Chan, F. (2018). How much of the response to selection can be attributed to discrete genes? In Population, Evolutionary, and Quantitative Genetics Conference (PEQG 2018) (pp. 116).


Cite as: https://hdl.handle.net/21.11116/0000-000D-4C3A-E
Abstract
When analysing a selection experiment, a natural null model is the infinitesimal with linkage: genetic variance is spread evenly along the genome. Under this model, even strong selection has only a modest effect on allele frequencies - though it does increase the fraction of extreme allele frequency shifts. Such extreme shifts are difficult to distinguish from sweeps due to discrete loci, making it hard to attribute much of the selection response to specific genes. These arguments will be illustrated by an experiment that selected for longer-legged mice.