Toward Microbiome Engineering: Expanding the Repertoire of Genetically 
Tractable Members of the Human Gut Microbiome

Marsh, JW; Kirk, C; Ley, RE

doi:10.1146/annurev-micro-032421-112304

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Toward Microbiome Engineering: Expanding the Repertoire of Genetically Tractable Members of the Human Gut Microbiome

MPS-Authors

/persons/resource/persons270521

Marsh, JW
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;
Microbiome Engineering Group, Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons286397

Kirk, C
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;
Microbiome Engineering Group, Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons270516

Ley, RE
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Marsh, J., Kirk, C., & Ley, R. (2023). Toward Microbiome Engineering: Expanding the Repertoire of Genetically Tractable Members of the Human Gut Microbiome. Annual Review of Microbiology, 77, 427-449. doi:10.1146/annurev-micro-032421-112304.

引用: https://hdl.handle.net/21.11116/0000-000D-52BC-3

要旨

Genetic manipulation is necessary to interrogate the functions of microbes in their environments, such as the human gut microbiome. Yet, the vast majority of human gut microbiome species are not genetically tractable. Here, we review the hurdles to seizing genetic control of more species. We address the barriers preventing the application of genetic techniques to gut microbes and report on genetic systems currently under development. While methods aimed at genetically transforming many species simultaneously in situ show promise, they are unable to overcome many of the same challenges that exist for individual microbes. Unless a major conceptual breakthrough emerges, the genetic tractability of the microbiome will remain an arduous task. Increasing the list of genetically tractable organisms from the human gut remains one of the highest priorities for microbiome research and will provide the foundation for microbiome engineering. Expected final online publication date for the Annual Review of Microbiology, Volume 77 is September 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.