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Genome-wide patterns of selection in the nematode Pristionchus pacificus

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Rödelsperger,  C       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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McGaughran,  A       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Moreno,  E       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Morgan,  K
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Meyer,  J
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Sommer,  R       
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Rödelsperger, C., McGaughran, A., Moreno, E., Morgan, K., Meyer, J., Grimm, D., et al. (2015). Genome-wide patterns of selection in the nematode Pristionchus pacificus. In 15th Congress of the European Society for Evolutionary Biology (ESEB 2015) (pp. 237).


Cite as: https://hdl.handle.net/21.11116/0000-000D-57E8-C
Abstract
The nematode Pristionchus pacificus has been established as a satellite model to Caenorhabditis elegans for comparative studies in developmental biology, ecology, and population genetics. Based on whole-genome sequencing of hundred globally sampled isolates, we have previously identified background selection as a major factor shaping genetic diversity. In this study, we investigate selective processes that act on top of background selection. To this end, we sequenced genomes of 218 isolates from the island la Reunion, which was previously identified as a hotspot of P. pacificus diversity. On this geographically diverse island, we identified several distinct P. pacificus populations (defined by location) that group into four evolutionary lineages. Despite the fact, that strains of distinct evolutionary lineages can be successfully crossed in the lab, there is almost no evidence for outcrossing across lineage borders in the wild. Focusing on population comparisons within lineages, we identified numerous genomic loci with almost complete differentiation between populations. These candidate loci for adaptation harbor several genes that were previously described as playing a role in chemosensation and pathogen resistance. In addition, we identified highly polymorphic variants near immune response related genes, that suggest the action of frequency dependent selection.