Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe 
of the porcine pituitary

Schwarz, H; Jagla, W; Wiede, A; Hoffmann, W

doi:10.1007/s004410100412

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Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary

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Schwarz, H
Electron Microscopy, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Schwarz, H., Jagla, W., Wiede, A., & Hoffmann, W. (2001). Ultrastructural co-localization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary. Cell and Tissue Research, 305(3), 411-416. doi:10.1007/s004410100412.

Cite as: https://hdl.handle.net/21.11116/0000-000D-5D0F-C

Abstract

TFF-peptides (formerly P-domain peptides, trefoil factors) are typical secretory products of many mucous epithelial cells. TFF3 is also synthesized in oxytocinergic neurons in the paraventricular and supraoptic nuclei of the human hypothalamus. Here, TFF3 and oxytocin are shown to be co-localized within the same secretory vesicles in the neural (posterior) lobe of the procine pituitary by means of immunoelectron microscopy. Relatively large amounts of TFF3, but not TFF1 and TFF2, are present in the neural lobe of the porcine pituitary, where it is probably released into the bloodstream.