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Dissociating distinct cortical networks associated with subregions of the human medial temporal lobe using precision neuroimaging

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Reznik,  Daniel
Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel,  Robert       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf,  Nikolaus       
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany;

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Doeller,  Christian F.       
Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Kavli Institute, Norwegian University of Science and Technology, Trondheim, Norway;
Wilhelm Wundt Institute for Psychology, University of Leipzig, Germany;
Faculty of Psychology, TU Dresden, Germany;

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Citation

Reznik, D., Trampel, R., Weiskopf, N., Witter, M. P., & Doeller, C. F. (2023). Dissociating distinct cortical networks associated with subregions of the human medial temporal lobe using precision neuroimaging. Neuron, 111(17), 2756-2772.e7. doi:10.1016/j.neuron.2023.05.029.


Cite as: https://hdl.handle.net/21.11116/0000-000D-67BF-9
Abstract
Tract-tracing studies in primates indicate that different subregions of the medial temporal lobe (MTL) are connected with multiple brain regions. However, no clear framework defining the distributed anatomy associated with the human MTL exists. This gap in knowledge originates in notoriously low MRI data quality in the anterior human MTL and in group-level blurring of idiosyncratic anatomy between adjacent brain regions, such as entorhinal and perirhinal cortices, and parahippocampal areas TH/TF. Using MRI, we intensively scanned four human individuals and collected whole-brain data with unprecedented MTL signal quality. Following detailed exploration of cortical networks associated with MTL subregions within each individual, we discovered three biologically meaningful networks associated with the entorhinal cortex, perirhinal cortex, and parahippocampal area TH, respectively. Our findings define the anatomical constraints within which human mnemonic functions must operate and are insightful for examining the evolutionary trajectory of the MTL connectivity across species.