Mutations affecting development of the midline and general body shape during 
zebrafish embryogenesis

Brand, M; Heisenberg, C-P; Warga, RM; Pelegri, F; Karlstrom, RO; Beuchle, D; Picker, A; Jiang, Y-J; Furutani-Seiki, M; van Eeden, FJM; Granato, M; Haffter, P; Hammerschmidt, M; Kane, DA; Kelsh, RN; Mullins, MC; Odenthal, J; Nüsslein-Volhard, C

doi:10.1242/dev.123.1.129

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学術論文

Mutations affecting development of the midline and general body shape during zebrafish embryogenesis

MPS-Authors

/persons/resource/persons219033

Brand, M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons219231

Heisenberg, C-P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274441

Warga, RM
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons285547

Pelegri, F
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons283877

Karlstrom, RO
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons277769

Beuchle, D
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons219535

Picker, A
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274433

Jiang, Y-J
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274429

Furutani-Seiki, M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274409

van Eeden, FJM
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274425

Granato, M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274411

Haffter, P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons191086

Hammerschmidt, M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274435

Kane, DA
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274437

Kelsh, RN
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274439

Mullins, MC
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274416

Odenthal, J
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271460

Nüsslein-Volhard, C
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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引用

Brand, M., Heisenberg, C.-P., Warga, R., Pelegri, F., Karlstrom, R., Beuchle, D., Picker, A., Jiang, Y.-J., Furutani-Seiki, M., van Eeden, F., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D., Kelsh, R., Mullins, M., Odenthal, J., & Nüsslein-Volhard, C. (1996). Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development, 123, 129-142. doi:10.1242/dev.123.1.129.

引用: https://hdl.handle.net/21.11116/0000-000D-6FA6-C

要旨

Tissues of the dorsal midline of vertebrate embryos, such as notochord and floor plate, have been implicated in inductive interactions that pattern the neural tube and somites. In our screen for embryonic visible mutations in the zebrafish we found 113 mutations in more than 27 genes with altered body shape, often with additional defects in CNS development. We concentrated on a subgroup of mutations in ten genes (the midline-group) that cause defective development of the floor plate. By using floor plate markers, such as the signaling molecule sonic hedgehog, we show that the schmalspur (sur) gene is needed for early floor plate development, similar to one-eyed-pinhead (oep) and the previously described cyclops (cyc) gene. In contrast to oep and cyc, sur embryos show deletions of ventral CNS tissue restricted to the mid- and hindbrain, whereas the forebrain appears largely unaffected. In the underlying mesendodermal tissue of the head, sur is needed only for development of the posterior prechordal plate, whereas oep and cyc are required for both anterior and posterior prechordal plate development. Our analysis of sur mutants suggests that defects within the posterior prechordal plate may cause aberrant development of ventral CNS structures in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you-too, sonic-you, iguana, detour, schmalhans and monorail embryos; these mutants often show additional defects in tissues that are known to depend on signals from notochord and floor plate. For example, sur, con and yot mutants show reduction of motor neurons; median deletions of brain tissue are seen in sur, con and yot embryos; and cyc, con, yot, igu and dtr mutants often show no or abnormal formation of the optic chiasm. We also find fusions of the ventral neurocranium for all midline mutants tested, which may reveal a hitherto unrecognized function of the midline in influencing differentiation of neural crest cells at their destination. As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues.