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Linker, loading, and reaction scale influence automated glycan assembly

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Dal Colle,  Marlene
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Garcia Ricardo,  Manuel       
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Hribernik,  Nives       
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Danglad-Flores,  José Angél       
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.       
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Delbianco,  Martina
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Dal Colle, M., Garcia Ricardo, M., Hribernik, N., Danglad-Flores, J. A., Seeberger, P. H., & Delbianco, M. (2023). Linker, loading, and reaction scale influence automated glycan assembly. Beilstein Journal of Organic Chemistry, 19, 1015-1020. doi:10.3762/bjoc.19.77.


Cite as: https://hdl.handle.net/21.11116/0000-000D-702D-3
Abstract
Automated glycan assembly (AGA) affords collections of well-defined glycans in a short amount of time. We systematically analyzed how parameters connected to the solid support affect the AGA outcome for three different glycan sequences. We showed that, while loading and reaction scale did not significantly influence the AGA outcome, the chemical nature of the linker dramatically altered the isolated yields. We identified that the major determinants of AGA yields are cleavage from the solid support and post-AGA purification steps.