Ubiquitination and cell-autonomous immunity

Mello-Vieira, João; Bopp, Tobias; Đikić, Ivan

doi:10.1016/j.coi.2023.102368

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Ubiquitination and cell-autonomous immunity

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Đikić, Ivan
Institute of Biochemistry II, Medical Faculty, Goethe-University, Frankfurt am Main, Germany;
Buchmann Institute for Molecular Life Sciences, Frankfurt am Main, Germany;
Max Planck Fellow Group ER remodelling Group, Prof. Ivan Đikić, Max Planck Institute of Biophysics, Max Planck Society;

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引用

Mello-Vieira, J., Bopp, T., & Đikić, I. (2023). Ubiquitination and cell-autonomous immunity. Current Opinion in Immunology, 84:. doi:10.1016/j.coi.2023.102368.

引用: https://hdl.handle.net/21.11116/0000-000D-73EA-A

要旨

Cell-autonomous immunity is the first line of defense by which cells recognize and contribute to eliminating invasive pathogens. It is composed of immune signaling networks that sense microbial pathogens, promote pathogen restriction, and stimulate their elimination, including host cell death. Ubiquitination is a pivotal orchestrator of these pathways, by changing the activity of signal transducers and effector proteins in an efficient way. In this review, we will focus on how ubiquitin connects the pathways that sense pathogens to the cellular responses to invaders and shed light on how ubiquitination impacts the microenvironment around the infected cell, stimulating the appropriate immune response. Finally, we discuss therapeutic options directed at favoring cell-autonomous immune responses to infection.