A corollary discharge mediates saccade-related inhibition of single units in 
mnemonic structures of the human brain

Katz, Chaim N.; Schjetnan, Andrea G.P.; Patel, Kramay; Barkley, Victoria; Hoffman, Kari L.; Kalia, Suneil K.; Duncan, Katherine D.; Valiante, Taufik A.

doi:10.1016/j.cub.2022.06.015

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Journal Article

A corollary discharge mediates saccade-related inhibition of single units in mnemonic structures of the human brain

MPS-Authors

Valiante, Taufik A.
External Organizations;
Max Planck - University of Toronto Centre for Neural Science and Technology, Max Planck Institute of Microstructure Physics, Max Planck Society;

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https://doi.org/10.1016/j.cub.2022.06.015
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Citation

Katz, C. N., Schjetnan, A. G., Patel, K., Barkley, V., Hoffman, K. L., Kalia, S. K., et al. (2022). A corollary discharge mediates saccade-related inhibition of single units in mnemonic structures of the human brain. Current Biology, 32(14), 3082-3094.e4. doi:10.1016/j.cub.2022.06.015.

Cite as: https://hdl.handle.net/21.11116/0000-000D-8E62-5

Abstract

Despite the critical link between visual exploration and memory, little is known about how neuronal activity in the human mesial temporal lobe (MTL) is modulated by saccades. Here, we characterize saccade-associated neuronal modulations, unit-by-unit, and contrast them to image onset and to occipital lobe neurons. We reveal evidence for a corollary discharge (CD)-like modulatory signal that accompanies saccades, inhibiting/exciting a unique population of broad-/narrow-spiking units, respectively, before and during saccades and with directional selectivity. These findings comport well with the timing, directional nature, and inhibitory circuit implementation of a CD. Additionally, by linking neuronal activity to event-related potentials (ERPs), which are directionally modulated following saccades, we recontextualize the ERP associated with saccades as a proxy for both the strength of inhibition and saccade direction, providing a mechanistic underpinning for the more commonly recorded saccade-related ERP in the human brain.