In the mouse cortex, oligodendrocytes regain a plastic capacity, transforming 
into astrocytes after acute injury

Bai, Xianshu; Zhao, Na; Koupourtidou, Christina; Fang, Li-Pao; Schwarz, Veronika; Caudal, Laura C.; Zhao, Renping; Hirrlinger, Johannes; Walz, Wolfgang; Bian, Shan; Huang, Wenhui; Ninkovic, Jovica; Kirchhoff, Frank; Scheller, Anja

doi:10.1016/j.devcel.2023.04.016

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In the mouse cortex, oligodendrocytes regain a plastic capacity, transforming into astrocytes after acute injury

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Hirrlinger, Johannes
Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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引用

Bai, X., Zhao, N., Koupourtidou, C., Fang, L.-P., Schwarz, V., Caudal, L. C., Zhao, R., Hirrlinger, J., Walz, W., Bian, S., Huang, W., Ninkovic, J., Kirchhoff, F., & Scheller, A. (2023). In the mouse cortex, oligodendrocytes regain a plastic capacity, transforming into astrocytes after acute injury. Developmental Cell, 58(13), 1153-1169.e5. doi:10.1016/j.devcel.2023.04.016.

引用: https://hdl.handle.net/21.11116/0000-000D-BDE1-0

要旨

Acute brain injuries evoke various response cascades directing the formation of the glial scar. Here, we report that acute lesions associated with hemorrhagic injuries trigger a re-programming of oligodendrocytes. Single-cell RNA sequencing highlighted a subpopulation of oligodendrocytes activating astroglial genes after acute brain injuries. By using PLP-DsRed1/GFAP-EGFP and PLP-EGFP_mem/GFAP-mRFP1 transgenic mice, we visualized this population of oligodendrocytes that we termed AO cells based on their concomitant activity of astro- and oligodendroglial genes. By fate mapping using PLP- and GFAP-split Cre complementation and repeated chronic in vivo imaging with two-photon laser-scanning microscopy, we observed the conversion of oligodendrocytes into astrocytes via the AO cell stage. Such conversion was promoted by local injection of IL-6 and was diminished by IL-6 receptor-neutralizing antibody as well as by inhibiting microglial activation with minocycline. In summary, our findings highlight the plastic potential of oligodendrocytes in acute brain trauma due to microglia-derived IL-6.