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Journal Article

dMi-2, a hunchback-interacting protein that functions in polycomb repression

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Kehle,  J
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Beuchle,  D
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Treuheit,  S
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Kehle, J., Beuchle, D., Treuheit, S., Christen, B., Kennison, J., Bienz, A., et al. (1998). dMi-2, a hunchback-interacting protein that functions in polycomb repression. Science, 282(5395), 1897-1900. doi:10.1126/science.282.5395.1897.


Cite as: https://hdl.handle.net/21.11116/0000-000D-9F19-5
Abstract
Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.