twist and snail as positive and negative regulators during Drosophila mesoderm 
development

Leptin, M

doi:10.1101/gad.5.9.1568

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

twist and snail as positive and negative regulators during Drosophila mesoderm development

MPS-Authors

/persons/resource/persons282845

Leptin, M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Leptin, M. (1991). twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes and Development, 5(9), 1568-1576. doi:10.1101/gad.5.9.1568.

Cite as: https://hdl.handle.net/21.11116/0000-000D-A5F3-6

Abstract

twist and snail are members of the helix-loop-helix and zinc-finger protein families, respectively, and determine the development of the mesoderm in Drosophila. This paper analyzes their role in mesoderm development by examining how they affect the expression of downstream genes. twist and snail act by regulating gene expression in the mesoderm and in neighboring regions, and have distinct roles in this process. snail prevents expression in the mesoderm of genes that are destined to be active only in more lateral or dorsal regions. twist is required for the activation of downstream mesodermal genes. twist is also required for the full expression of snail and for the maintenance of its own expression. Only the absence of both twist and snail results in the complete loss of all mesodermal characteristics.