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Cross-linking reactions in Langmuir monolayers of specially designed aminolipids : a toolbox for the customized production of amphiphilic nanosheets

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Stefaniu,  Cristina
Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Latza,  Victoria Maria
Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Brezesinski,  Gerald
Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Schneck,  Emanuel       
Emanuel Schneck, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Stefaniu, C., Wölk, C., Latza, V. M., Chumakov, A., Brezesinski, G., & Schneck, E. (2023). Cross-linking reactions in Langmuir monolayers of specially designed aminolipids: a toolbox for the customized production of amphiphilic nanosheets. Nanoscale Advances, 5(17), 4589-4597. doi:10.1039/d3na00244f.


Cite as: https://hdl.handle.net/21.11116/0000-000D-A7A2-F
Abstract
Synthetic amino lipids, already known as highly efficient gene therapy tool, are used in a novel way to create cross-linked stable one-molecule-thin films envisioned for future (bio)-materials applications. The films are prepared as Langmuir monolayers at the air/water interface and cross-linked ‘in situ’ via dynamic imine chemistry. The cross-linking process and the film characteristics are monitored by various surface-sensitive techniques such as grazing incidence X-ray diffraction, X-ray reflectivity, and infrared reflection–absorption spectroscopy. After transfer onto carbon grids, the cross-linked films are investigated by transmission and scanning electron microscopy. The obtained micrographs display mechanically self-supported nanosheets with area dimensions over several micrometers and, thus, an undeniable visual proof of successful cross-linking. The cross-linking process at the air/water interface allows to obtain Janus-faced sheets with a hydrophobic side characterized by aliphatic alkyl chains and a hydrophilic side characterized by nucleophilic groups like amines, hydroxyl groups and imine.