English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish

MPS-Authors
/persons/resource/persons274411

Haffter,  P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C., & Moens, C. (2000). lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Molecular Cell, 6(2), 255-267. doi:10.1016/s1097-2765(00)00027-7.


Cite as: https://hdl.handle.net/21.11116/0000-000D-A92E-2
Abstract
Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.