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Journal Article

lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish


Haffter,  P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C., & Moens, C. (2000). lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Molecular Cell, 6(2), 255-267. doi:10.1016/s1097-2765(00)00027-7.

Cite as: https://hdl.handle.net/21.11116/0000-000D-A92E-2
Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.