lazarus is a novel pbx gene that globally mediates hox gene function in 
zebrafish

Pöpperl, H; Rikhof, H; Chang, H; Haffter, P; Kimmel, CB; Moens, CB

doi:10.1016/s1097-2765(00)00027-7

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish

MPS-Authors

/persons/resource/persons274411

Haffter, P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Pöpperl, H., Rikhof, H., Chang, H., Haffter, P., Kimmel, C., & Moens, C. (2000). lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish. Molecular Cell, 6(2), 255-267. doi:10.1016/s1097-2765(00)00027-7.

引用: https://hdl.handle.net/21.11116/0000-000D-A92E-2

要旨

Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain proteins. Here, we report the identification and cloning of a zebrafish gene, lazarus, which is required globally for segmental patterning in the hindbrain and anterior trunk. We show that lazarus is a novel pbx gene and provide evidence that it is the primary pbx gene required for the functions of multiple hox genes during zebrafish development. lazarus plays a critical role in orchestrating the corresponding segmentation of the hindbrain and the pharyngeal arches, a key step in the development of the vertebrate body plan.