Patterning of the mesoderm involves several threshold responses to BMP-4 and 
Xwnt-8

Marom, K; Fainsod, A; Steinbeisser, H

doi:10.1016/s0925-4773(99)00137-9

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Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8

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Steinbeisser, H
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Marom, K., Fainsod, A., & Steinbeisser, H. (1998). Patterning of the mesoderm involves several threshold responses to BMP-4 and Xwnt-8. Mechanisms of Development, 87(1-2), 33-44. doi:10.1016/s0925-4773(99)00137-9.

Cite as: https://hdl.handle.net/21.11116/0000-000D-AE90-C

Abstract

Two secreted signaling molecules, Xwnt-8 and BMP-4, play an essential role in the dorso-ventral patterning of the mesoderm in Xenopus. Here we investigate how the Wnt-8 and the BMP-4 pathways are connected and how they regulate target genes in the lateral and ventral marginal zone. BMP-4 regulates the transcription of Xwnt-8 in a threshold dependent manner. High levels of BMP-4 induce the expression of the Wnt antagonist sizzled in the ventral marginal zone, independent of Xwnt-8 signaling. Xwnt-8 induces the early muscle marker myf-5 in the lateral marginal zone in a BMP independent manner. The expression of the homeobox gene Xvent-1 can be modulated through both the BMP-4 and the Xwnt-8 pathways. The spatial distribution and the level of BMP-4 activity in the lateral and ventral marginal zone is reflected in the dynamic expression pattern of Xwnt-8. The data support the view that Xwnt-8 is involved in the specification of lateral (somitogenic) mesoderm and BMP-4 in the specification of ventral mesoderm.