English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Conserved Spätzle/Toll signaling in dorsoventral patterning of Xenopus embryos

MPS-Authors
/persons/resource/persons277072

Steinbeisser,  H
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Armstrong, N., Steinbeisser, H., Prothmann, C., DeLotto, R., & Rupp, R. (1998). Conserved Spätzle/Toll signaling in dorsoventral patterning of Xenopus embryos. Mechanisms of Development, 71(1-2), 99-105. doi:10.1016/s0925-4773(98)00003-3.


Cite as: https://hdl.handle.net/21.11116/0000-000D-B218-F
Abstract
The Spätzle/Toll signaling pathway controls ventral axis formation in Drosophila by generating a gradient of nuclear Dorsal protein. Dorsal controls the downstream regulators dpp and sog, whose patterning functions are conserved between insects and vertebrates. Although there is no experimental evidence that the upstream events are conserved as well, we set out to ask if a vertebrate embryo can respond to maternal components of the fly Dorsal pathway. Here we demonstrate a dorsalizing activity for the heterologous Easter, Spätzle and Toll proteins in UV-ventralized Xenopus embryos, which is inhibited by a co-injected dominant Cactus variant. We conclude that the Dorsal signaling pathway is a component of the conserved dorsoventral (d/v) patterning system in bilateria.