CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in 
Solanum lycopersicum

Martinho, C; Wang, Z; Ghigi, A; Buddle, S; Barbour, F; Yarur, A; Gouil, Q; Müller, S; Stam, M; Liu, C; Baulcombe, DC

doi:10.1073/pnas.2112240119

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CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum

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Martinho, C., Wang, Z., Ghigi, A., Buddle, S., Barbour, F., Yarur, A., et al. (2022). CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintains the sulfurea paramutation in Solanum lycopersicum. Proceedings of the National Academy of Sciences of the United States of America, 119(13): e2112240119. doi:10.1073/pnas.2112240119.

Cite as: https://hdl.handle.net/21.11116/0000-000D-B513-1

Abstract

SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance of conspicuous phenotypes in maize but also in other plants and animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. It may be a consequence of wide-cross hybridization and may contribute to quantitative trait variation or unstable phenotypes in crops. Using the sulfurea (sulf) locus in tomato, we demonstrate that a self-reinforcing feedback loop involving DNA- and histone-methyl transferases CHROMOMETHYLTRANSFERASE3 (CMT3) and KRYPTONITE (KYP) is required for paramutation of sulf and that there is a change in chromatin organization. These findings advance the understanding of non-Mendelian inheritance in plants.