Decoding a ribosome uncertainty

Duss, Olivier; Nikolay, Rainer; Kraushar, Matthew L.

doi:10.1016/j.tig.2023.06.001

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Decoding a ribosome uncertainty

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Nikolay, Rainer
High-Resolution Neurogenetics (Matthew Kraushar), Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Kraushar, Matthew L.
High-Resolution Neurogenetics (Matthew Kraushar), Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Duss, O., Nikolay, R., & Kraushar, M. L. (2023). Decoding a ribosome uncertainty. Trends in Genetics, 39(9), 639-641. doi:10.1016/j.tig.2023.06.001.

Cite as: https://hdl.handle.net/21.11116/0000-000D-C19D-8

Abstract

The ribosome is among the most ancient macromolecular complexes. Throughout evolution, the function of the ribosome has remained essential and conserved: the decoding of an mRNA template with tRNA-linked amino acids, to synthesize a protein. In a recent study, Holm et al. capture evolutionary distinctions in the structure and kinetics of 'mRNA decoding' by the human ribosome.