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Journal Article

Recyclable and robust optical nanoprobes with engineered enzymes for sustainable serodiagnostics

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Liu,  Yuxin       
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Löffler,  Felix F.
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Liu, Y., Wei, Z., Damian, M., Zhu, X., Knaus, T., Zhang, H., et al. (2023). Recyclable and robust optical nanoprobes with engineered enzymes for sustainable serodiagnostics. Advanced Materials, 35(47): 2306615. doi:10.1002/adma.202306615.


Cite as: https://hdl.handle.net/21.11116/0000-000D-C2E5-5
Abstract
Recyclable fluorescence assays that can be stored at room temperature would greatly benefit biomedical diagnostics by bringing sustainability and cost-efficiency, especially for point-of-care serodiagnostics in developing regions. Here, a general strategy is proposed to generate recyclable fluorescent probes by using engineered enzymes with enhanced thermo-/chemo-stability, which maintains an outstanding serodiagnostic performance (accuracy >95%) after 10 times of recycling as well as after storage at elevated temperatures (37°C for 10 days). With these three outstanding properties, recyclable fluorescent probes can be designed to detect various biomarkers of clinical importance by using different enzymes.