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Journal Article

Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle

MPS-Authors
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Zsido,  Rachel       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Serio,  Bianca       
Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Mildner,  Toralf
Methods and Development Group Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel,  Robert       
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Beyer,  Frauke       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Witte,  A. Veronica       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Sacher,  Julia       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zsido_2023.pdf
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Citation

Zsido, R., Williams, A. N., Barth, C., Serio, B., Kurth, L., Mildner, T., et al. (2023). Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle. Nature Mental Health, (1), 761-771. doi:10.1038/s44220-023-00125-w.


Cite as: https://hdl.handle.net/21.11116/0000-000D-C45F-C
Abstract
Ovarian hormones have substantial effects on the brain, and early menopause has been associated with increased risk of accelerated brain aging and dementia later in life. However, the impact of ovarian hormone fluctuations on brain structure earlier in life is less understood. Here we show that ovarian hormone fluctuations shape structural brain plasticity during the reproductive years. We use longitudinal ultra-high field neuroimaging across the menstrual cycle to map the morphology of medial temporal lobe subregions in 27 participants. Controlling for water content and blood flow, our findings reveal positive associations between estradiol and parahippocampal cortex volume, progesterone and subiculum and perirhinal area 35 volumes, and an estradiol*progesterone interaction with CA1 volume. This research offers a blueprint for future studies on the shared dynamics of the brain and ovarian function and a fundamental stepping stone towards developing sex-specific strategies to improve brain health and mental health.