Bioelectrocatalytic CO2 Reduction by Mo-Dependent Formylmethanofuran 
Dehydrogenase

Sahin, Selmihan; Lemaire, Olivier N.; Belhamri, Mélissa; Kurth, Julia M.; Welte, Cornelia U.; Wagner, Tristan; Milton, Ross D.

doi:10.1002/anie.202311981

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Bioelectrocatalytic CO2 Reduction by Mo-Dependent Formylmethanofuran Dehydrogenase

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Lemaire, Olivier N.
Research Group Microbial Metabolism, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Belhamri, Mélissa
Research Group Microbial Metabolism, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Wagner, Tristan
Research Group Microbial Metabolism, Max Planck Institute for Marine Microbiology, Max Planck Society;

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Citation

Sahin, S., Lemaire, O. N., Belhamri, M., Kurth, J. M., Welte, C. U., Wagner, T., et al. (2023). Bioelectrocatalytic CO2 Reduction by Mo-Dependent Formylmethanofuran Dehydrogenase. Angewandte Chemie, International Edition in English. doi:10.1002/anie.202311981.

Cite as: https://hdl.handle.net/21.11116/0000-000D-CB42-4

Abstract

Massiveeffortsare investedin developinginnovativeCO2-sequestrationstrategiesto counterclimatechangeandtransformCO2intohigher-valueproducts.CO2-captureby reductionis a chemicalchallenge,andattentionis turnedtowardbiologicalsystemsthatselectivelyandefficientlycatalysethisreactionundermildconditionsandin aqueoussolvents.Whilea fewreportshaveevaluatedthe effectivenessof isolatedbacterialformatedehydrogenasesas catalystsforthereversibleelectrochemicalreductionof CO2, it is imperativeto exploreotherenzymesamongthenaturalreservoirof potentialmodelsthatmightexhibithigherturnoverratesor preferentialdirectionalityfor thereductivereaction.Here,we presentelectroenzymaticcatalysisof formylmethanofurandehydrogenase,a CO2-reducing-and-fixingbiomachineryisolatedfroma thermophilicmethanogen,whichwasdepositedon a graphiterodelectrodeto enabledirectelectrontransferfor electroenzymaticCO2reduction.Thegas is reducedwitha highFaradaicefficiency(109�1%),wherea lowaffinityfor formatepreventsits electrochemicalreoxidationandfavoursformateaccumulation.Thesepropertiesmakethe enzymean excellenttoolfor electroenzymaticCO2-fixationandinspirationfor proteinengineeringthatwouldbe beneficialfor biotechnologicalpurposesto convertthegreenhousegasintostableformatethatcansubsequentlybe safelystored,transported,andusedfor powergenerationwithoutenergyloss.