How Nutrition Regulates Hematopoietic Stem Cell Features

Schönberger, Katharina; Cabezas-Wallscheid, Nina

doi:10.1016/j.exphem.2023.09.008

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How Nutrition Regulates Hematopoietic Stem Cell Features

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Schönberger, Katharina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Cabezas-Wallscheid, Nina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S0301472X23017356?via%3Dihub
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Citation

Schönberger, K., & Cabezas-Wallscheid, N. (2023). How Nutrition Regulates Hematopoietic Stem Cell Features. Experimental Hematology, 128, 10-18. doi:10.1016/j.exphem.2023.09.008.

Cite as: https://hdl.handle.net/21.11116/0000-000D-CF06-4

Abstract

Our dietary choices significantly impact all the cells in our body. Increasing evidence suggests that diet-derived metabolites influence hematopoietic stem cell (HSC) metabolism and function, thereby actively modulating blood homeostasis. This is of particular relevance since regulating the metabolic activity of HSCs is crucial for maintaining stem cell fitness and mitigating the risk of hematological disorders. In this review, we examine the current scientific knowledge of the impact of the diet on stemness features, and we specifically highlight the established mechanisms by which dietary components modulate metabolic and transcriptional programs in adult HSCs. Gaining a deeper understanding of how nutrition influences our HSC compartment may pave the way for targeted dietary interventions with the potential to decelerate aging and improve the effectiveness of transplantation and cancer therapies.