Nanoscale nuclear magnetic resonance with chemical resolution

Aslam, N.; Pfender, M.; Neumann, P.; Reuter, R.; Zappe, A.; de Oliveira, F.; Denisenko, A.; Sumiya, H.; Onoda, S.; Isoya, J.; Wrachtrup, J.

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Journal Article

Nanoscale nuclear magnetic resonance with chemical resolution

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Wrachtrup, J.
Max Planck Society;

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Aslam, N., Pfender, M., Neumann, P., Reuter, R., Zappe, A., de Oliveira, F., et al. (2017). Nanoscale nuclear magnetic resonance with chemical resolution. Science, 357(6346), 67-71.

Cite as: https://hdl.handle.net/21.11116/0000-000E-D4B4-7

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a key analytical technique in chemistry, biology, and medicine. However, conventional NMR spectroscopy requires an at least nanoliter-sized sample volume to achieve sufficient signal. We combined the use of a quantum memory and high magnetic fields with a dedicated quantum sensor based on nitrogen vacancy centers in diamond to achieve chemical shift resolution in H-1 and F-19 NMR spectroscopy of 20-zeptoliter sample volumes. We demonstrate the application of NMR pulse sequences to achieve homonuclear decoupling and spin diffusion measurements. The best measured NMR linewidth of a liquid sample was similar to 1 part per million, mainly limited by molecular diffusion. To mitigate the influence of diffusion, we performed high-resolution solid-state NMR by applying homonuclear decoupling and achieved a 20-fold narrowing of the NMR linewidth.