Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple 
Sclerosis

Ontaneda, D; Gulani, V; Deshmane, A; Shah, A; Guruprakash, DK; Jiang, Y; Ma, D; Lee, J-C; Fisher, E; Rudick, RA; Raza, P; Kilbane, M; Cohen, JK; Sakaie, K; Lowe , MJ; Griswold, MA; Nakamura, K

doi:10.1016/j.msard.2023.105024

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis

MPS-Authors

/persons/resource/persons215996

Deshmane, A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://www.sciencedirect.com/science/article/abs/pii/S2211034823005254
(出版社版)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Ontaneda, D., Gulani, V., Deshmane, A., Shah, A., Guruprakash, D., Jiang, Y., Ma, D., Lee, J.-C., Fisher, E., Rudick, R., Raza, P., Kilbane, M., Cohen, J., Sakaie, K., Lowe, M., Griswold, M., & Nakamura, K. (2023). Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis. Multiple Sclerosis and Related Disorders, 79:. doi:10.1016/j.msard.2023.105024.

引用: https://hdl.handle.net/21.11116/0000-000D-D0AA-8

要旨

Background: In this cross sectional study, we used MRF to investigate tissue properties of normal-appearing white matter, gray matter, and lesions in relapsing remitting MS (n = 21), secondary progressive MS (n = 16) and healthy controls (n = 9). A FISP-based MRF sequence was used for acquisition, imaging time 5 min 15 s. MRF T1 and T2 relaxation times were measured from lesional tissue, normal-appearing frontal white matter, corpus callous, thalamus, and caudate. Differences between healthy controls and MS were examined using ANCOVA adjusted for age and sex. Spearman rank correlations were assessed between T1 and T2 relaxation times and clinical measures.
Objectives: To examine brain T1 and T2 values using magnetic resonance fingerprinting (MRF) in healthy controls and MS.
Methods: The subjects included 21 relapsing-remitting (RR) MS, 16 secondary progressive (SP) MS, and 9 age- and sex-matched HC without manifest neurological disease participating in a longitudinal MRI study. A 3T/ FISP-based MRF sequence was acquired. Regions of interest were drawn for lesions and normal appearing white matter. ANCOVA adjusted for age and sex were used to compare the groups with significance set at 0.05.
Results: A step-wise increase in T1 and T2 relaxation times was found between healthy controls, relapsing remitting MS, and secondary progressive MS. Significant differences were found in T1 and T2 between MS and healthy controls in the frontal normal-appearing white matter, corpus callosum, and thalamus (p < 0.04 for all). Significant differences in T1 and T2 between RR and SPMS were found in the frontal normal-appearing white matter and T2 lesions (p < 0.02 for all). T1 relaxation from the frontal normal-appearing white matter correlated with the Expanded Disability Status Scale [ρ = 0.62, p < 0.001], timed 25 foot walk (ρ = 0.45, p = 0.01), 9 hole peg test (ρ = 0.62, p < 0.001), and paced auditory serial addition test (ρ = -0.4, p = 0.01).
Conclusion: These results suggest that MRF may be a clinically feasible quantitative approach for characterizing tissue damage in MS.