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Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia

MPS-Authors

Ayyıldız,  Nazife
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Interdisciplinary Neuroscience, Health Sciences Institute and Brain Research Center, Ankara University, Turkey;

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Beyer,  Frauke       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Anwander,  Alfred       
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Witte,  A. Veronica       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Ayyildiz_2023.pdf
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Ayyildiz_pre.pdf
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Ayyildiz_2023_Suppl.pdf
(Supplementary material), 874KB

Citation

Ayyıldız, N., Beyer, F., Üstün, S., Kale, E. H., Mançe Çalışır, Ö., Uran, P., et al. (2023). Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia. Frontiers in Human Neuroscience, 17: 1147352. doi:10.3389/fnhum.2023.1147352.


Cite as: https://hdl.handle.net/21.11116/0000-000D-DB0E-E
Abstract
Developmental dyscalculia is a neurodevelopmental disorder specific to arithmetic learning even with normal intelligence and age-appropriate education. Difficulties often persist from childhood through adulthood lowering the individual's quality of life. However, the neural correlates of developmental dyscalculia are poorly understood. This study aimed to identify brain structural connectivity alterations in developmental dyscalculia. All participants were recruited from a large scale, non-referred population sample in a longitudinal design. We studied 10 children with developmental dyscalculia (11.3 ± 0.7 years) and 16 typically developing peers (11.2 ± 0.6 years) using diffusion-weighted magnetic resonance imaging. We assessed white matter microstructure with tract-based spatial statistics in regions-of-interest tracts that had previously been related to math ability in children. Then we used global probabilistic tractography for the first time to measure and compare tract length between developmental dyscalculia and typically developing groups. The high angular resolution diffusion-weighted magnetic resonance imaging and crossing-fiber probabilistic tractography allowed us to evaluate the length of the pathways compared to previous studies. The major findings of our study were reduced white matter coherence and shorter tract length of the left superior longitudinal/arcuate fasciculus and left anterior thalamic radiation in the developmental dyscalculia group. Furthermore, the lower white matter coherence and shorter pathways tended to be associated with the lower math performance. These results from the regional analyses indicate that learning, memory and language-related pathways in the left hemisphere might be related to developmental dyscalculia in children.