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Journal Article

Differential regulation of c-JUN expression in rat retinal ganglion cells after proximal and distal optic nerve transection

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Hüll,  M
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Bähr,  M
Department Physical Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Hüll, M., & Bähr, M. (1994). Differential regulation of c-JUN expression in rat retinal ganglion cells after proximal and distal optic nerve transection. Neuroscience Letters, 178(1), 39-42. doi:10.1016/0304-3940(94)90284-4.


Cite as: https://hdl.handle.net/21.11116/0000-000D-F4A3-7
Abstract
In adult rats, the distance between the site of axotomy and the cell body influences the ability of retinal ganglion cells (RGCs) to survive and regenerate an axon. Optic nerves of adult rats were transected 2 mm or 6 mm from the optic bulb and RGCs labeled with the fluorescent marker fluorogold. The time course of c-JUN expression was monitored immunocytochemically between 3 days and 4 weeks after axotomy. c-JUN expression began later and declined faster after distal axotomy than after proximal transection of the optic nerve. However, at the same time significantly more RGCs survived after distal than after proximal axotomy 3 and 4 weeks after axotomy. These findings suggest that survival and expression of c-JUN in rat RGCs are independently regulated by the length of the optic nerve stump after lesion.