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Journal Article

Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II

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Magielse,  Neville
Institute of Neuroscience and Medicine, Research Center Jülich, Germany;
Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany;

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Heuer,  Katja
Unité de Neuroanatomie Appliquée et Théorique, Institut Pasteur, Paris, France;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Valk,  Sofie L.       
Institute of Neuroscience and Medicine, Research Center Jülich, Germany;
Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany;

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Magielse_2023.pdf
(Publisher version), 4MB

Supplementary Material (public)

Magielse_2023_Suppl.pdf
(Supplementary material), 3MB

Magielse_2023_Suppl1.pdf
(Supplementary material), 87KB

Magielse_2023_Suppl2.xlsx
(Supplementary material), 10KB

Magielse_2023_Suppl3.xlsx
(Supplementary material), 91KB

Citation

Magielse, N., Toro, R., Steigauf, V., Abbaspour, M., Eickhoff, S. B., Heuer, K., et al. (2023). Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II. Communications Biology, 6(1): 1188. doi:10.1038/s42003-023-05553-z.


Cite as: https://hdl.handle.net/21.11116/0000-000D-FAC4-C
Abstract
The reciprocal connections between the cerebellum and the cerebrum have been suggested to simultaneously play a role in brain size increase and to support a broad array of brain functions in primates. The cerebello-cerebral system has undergone marked functionally relevant reorganization. In particular, the lateral cerebellar lobules crura I-II (the ansiform) have been suggested to be expanded in hominoids. Here, we manually segmented 63 cerebella (34 primate species; 9 infraorders) and 30 ansiforms (13 species; 8 infraorders) to understand how their volumes have evolved over the primate lineage. Together, our analyses support proportional cerebellar-cerebral scaling, whereas ansiforms have expanded faster than the cerebellum and cerebrum. We did not find different scaling between strepsirrhines and haplorhines, nor between apes and non-apes. In sum, our study shows primate-general structural reorganization of the ansiform, relative to the cerebello-cerebral system, which is relevant for specialized brain functions in an evolutionary context.