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Investigating secretion systems and effectors on Galleria mellonella

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Habich,  Antonia
Guest Group Infection Biology (Unterweger), Max Planck Institute for Evolutionary Biology, Max Planck Society;
IMPRS for Evolutionary Biology, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Unterweger,  Daniel       
Guest Group Infection Biology (Unterweger), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Habich, A., & Unterweger, D. (2024). Investigating secretion systems and effectors on Galleria mellonella. In L. Journet, & E. Cascales (Eds.), Bacterial Secretion Systems (2, pp. 601-608). New York, NY: (Humana) Springer US. doi:10.1007/978-1-0716-3445-5_38.


Cite as: https://hdl.handle.net/21.11116/0000-000E-0615-4
Abstract
Infection experiments with Galleria mellonella enable the measurement of virulence that is mediated by secretion systems and their effector proteins in vivo. G. mellonella has an innate immune system and shares similarities with the complex host environment of mammals. Unlike other invertebrate model systems, experiments can be performed at mammalian body temperature. Here, we describe the systemic infection of G. mellonella with Pseudomonas aeruginosa with and without functional secretion systems. A Kaplan–Meier curve is constructed showing the percent survival of animals over time.