Genes That Bias Mendelian Segregation

Grognet, Pierre; Lalucque, Herve; Malagnac, Fabienne; Silar, Philippe

doi:10.1371/journal.pgen.1004387

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学術論文

Genes That Bias Mendelian Segregation

MPS-Authors

Grognet, Pierre
external;
Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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https://doi.org/10.1371/journal.pgen.1004387
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引用

Grognet, P., Lalucque, H., Malagnac, F., & Silar, P. (2014). Genes That Bias Mendelian Segregation. PLOS GENETICS, 10(5):. doi:10.1371/journal.pgen.1004387.

引用: https://hdl.handle.net/21.11116/0000-000E-0E75-0

要旨

Mendel laws of inheritance can be cheated by Meiotic Drive Elements
(MDs), complex nuclear genetic loci found in various eukaryotic genomes
and distorting segregation in their favor. Here, we identify and
characterize in the model fungus Podospora anserina Spok1 and Spok2, two
MDs known as Spore Killers. We show that they are related genes with
both spore-killing distorter and spore-protecting responder activities
carried out by the same allele. These alleles act as autonomous
elements, exert their effects independently of their location in the
genome and can act as MDs in other fungi. Additionally, Spok1 acts as a
resistance factor to Spok2 killing. Genetical data and cytological
analysis of Spok1 and Spok2 localization during the killing process
suggest a complex mode of action for Spok proteins. Spok1 and Spok2
belong to a multigene family prevalent in the genomes of many
ascomycetes. As they have no obvious cellular role, Spok1 and Spok2
Spore Killer genes represent a novel kind of selfish genetic elements
prevalent in fungal genome that proliferate through meiotic distortion.