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Journal Article

Overweight, Obesity and Meningioma Risk: A Meta-Analysis


Bai,  Li-Ping
Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Shao, C., Bai, L.-P., Qi, Z.-Y., Hui, G.-Z., & Wang, Z. (2014). Overweight, Obesity and Meningioma Risk: A Meta-Analysis. PLOS ONE, 9(2): e90167. doi:10.1371/journal.pone.0090167.

Cite as: https://hdl.handle.net/21.11116/0000-000E-0E70-5
Background and Objectives: Studies of the association between excess
body weight and risk of meningioma have produced inconsistent results.
Therefore, a meta-analysis of published studies was performed to better
assess the association between meningioma and excess body weight.
Methods: A literature search was conducted in the PubMed and EMBASE
databases without any limitations. The reference lists of identified
articles were also screened for additional studies. The summary relative
risks (RRs) and 95% confidence intervals (CI) were calculated using
fixed-or random-effects models.
Results: A total of 6 studies provided risk estimates for overweight or
obesity. Overall, the combined RRs were 1.12 (95% CI = 0.98-1.28) for
overweight and 1.45 (95% CI = 1.26-1.67) for obesity. After
stratification by gender, no significant association was observed for
obese men (RR = 1.30, 95% CI = 0.64-2.62), while significant association
was detected for obese women (RR = 1.46, 95% CI = 1.26-1.69). No
substantial differences emerged across strata of study design and
geographic areas.
Conclusion: The results of this meta-analysis suggest that obesity but
not overweight is associated with an increased risk of meningioma. Due
to the limited number of studies, further research is needed to confirm
the association.