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A method and server for predicting damaging missense mutations

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Schmidt,  S       
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Adzhubei, I., Schmidt, S., Peshkin, L., Ramensky, V., Gerasimova, A., Bork, P., et al. (2010). A method and server for predicting damaging missense mutations. Nature Methods, 7(4), 248-249. doi:10.1038/nmeth0410-248.


Cite as: https://hdl.handle.net/21.11116/0000-000E-1398-1
Abstract
Applications of rapidly advancing sequencing technologies exacerbate the need to interpret individual sequence variants. Sequencing of phenotyped clinical subjects will soon become a method of choice in studies of the genetic causes of Mendelian and complex diseases. New exon capture techniques will direct sequencing efforts towards the most informative and easily interpretable protein-coding fraction of the genome. Thus, the demand for computational predictions of the impact of protein sequence variants will continue to grow.