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Journal Article

Paramagnetic Lanthanide Chelates for Multicontrast MRI

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Truffault,  V       
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Cakić, N., Savić, T., Stricker-Shaver, J., Truffault, V., Platas-Iglesias, C., Mirkes, C., et al. (2016). Paramagnetic Lanthanide Chelates for Multicontrast MRI. Chemical Communications, 52(59), 9224-9227. doi:10.1039/C6CC04011J.


Cite as: https://hdl.handle.net/21.11116/0000-000E-13B3-2
Abstract
The preparation of a paramagnetic chelator that serves as platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or 19F MRI contrast agent is reported. Its europium(III) complex exhibits extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.