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Journal Article

Decreased long‐range temporal correlations in the resting‐state functional magentic resonance imaging blood‐oxygen‐level‐dependentsignal reflect motor sequence learning up to 2 weeks following training

MPS-Authors

Jäger,  Anna-Thekla
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Stroke Research, Charité University Medicine Berlin, Germany;
Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany;

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Huntenburg,  Julia M       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Tübingen, Germany;

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Villringer,  Arno       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Stroke Research, Charité University Medicine Berlin, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany;
Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany;

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Nikulin,  Vadim V.       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Bazin,  Pierre-Louis       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Social and Behavioural Science, University of Amsterdam, the Netherlands;

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Steele,  Christopher       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Physics, Concordia University, Montréal, QC, Canada;

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Jaeger_2023.pdf
(Publisher version), 3MB

Supplementary Material (public)

Jaeger_2023_Suppl1.png
(Supplementary material), 356KB

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(Supplementary material), 2MB

Jaeger_2023_Suppl3.png
(Supplementary material), 131KB

Citation

Jäger, A.-T., Bailey, A., Huntenburg, J. M., Tardif, C. L., Villringer, A., Gauthier, C. J., et al. (2024). Decreased long‐range temporal correlations in the resting‐state functional magentic resonance imaging blood‐oxygen‐level‐dependentsignal reflect motor sequence learning up to 2 weeks following training. Human Brain Mapping, 45(4): e26539. doi:10.1002/hbm.26539.


Cite as: https://hdl.handle.net/21.11116/0000-000E-1BB2-B
Abstract
Decreased long-range temporal correlations (LRTC) in brain signals can be used to measure cognitive effort during task execution. Here, we examined how learning a motor sequence affects long-range temporal memory within resting-state functional magnetic resonance imaging signal. Using the Hurst exponent (HE), we estimated voxel-wise LRTC and assessed changes over 5 consecutive days of training, followed by a retention scan 12 days later. The experimental group learned a complex visuomotor sequence while a complementary control group performed tightly matched movements. An interaction analysis revealed that HE decreases were specific to the complex sequence and occurred in well-known motor sequence learning associated regions including left supplementary motor area, left premotor cortex, left M1, left pars opercularis, bilateral thalamus, and right striatum. Five regions exhibited moderate to strong negative correlations with overall behavioral performance improvements. Following learning, HE values returned to pretraining levels in some regions, whereas in others, they remained decreased even 2 weeks after training. Our study presents new evidence of HE's possible relevance for functional plasticity during the resting-state and suggests that a cortical subset of sequence-specific regions may continue to represent a functional signature of learning reflected in decreased long-range temporal dependence after a period of inactivity.