Heterologous production of a cyanobacterial bacteriocin with potent 
antibacterial activity

Witthohn, Marco; Strieth, Dorina; Eggert, Simone; Kins, Stefan; Ulber, Roland; Muffler, Kai

doi:10.1016/j.crbiot.2021.10.002

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activity

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

1-s2.0-S2590262821000307-main.pdf
(Publisher version), 2MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Witthohn, M., Strieth, D., Eggert, S., Kins, S., Ulber, R., & Muffler, K. (2021). Heterologous production of a cyanobacterial bacteriocin with potent antibacterial activity. Current Research in Biotechnology, 3, 281-287. doi:10.1016/j.crbiot.2021.10.002.

Cite as: https://hdl.handle.net/21.11116/0000-000E-3BD0-5

Abstract

With regard to the emerging health threat by antibiotic resistant bacteria, bacteriocins are considered as a promising way to overcome this urgent problem. In this work, a hitherto unknown bacteriocin from the terrestrial cyanobacterium Chroococcidiopsis cubana was heterologously expressed in Escherichia coli, purified to homogeneity and tested for activity against several bacteria and one yeast species. The compound showed potent bacteriolytic activity against several Gram-positive bacteria and slight activity against one Gram-negative strain. The bacteriocin had no cytotoxic impact on mouse neuroblastoma N2a cells, indicating its potential for treatment against Gram-positive bacterial pathogens in human diseases.