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学術論文

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

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Czamara,  Darina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., Niu, Z., Zeng, X., Guan, W., Dou, J., Feinberg, J. I., Mordaunt, C., Pesce, G., Baiz, N., Alfano, R., Martens, D. S., Wang, C., Isaevska, E., Keikkala, E., Mustaniemi, S., Thio, C. H. L., Fraszczyk, E., Tobi, E. W., Starling, A. P., Cosin-Tomas, M., Urquiza, J., Roeder, S., Hoang, T. T., Page, C., Jima, D. D., House, J. S., Maguire, R. L., Ott, R., Pawlow, X., Sirignano, L., Zillich, L., Malmberg, A., Rauschert, S., Melton, P., Gong, T., Karlsson, R., Fore, R., Perng, W., Laubach, Z. M., Czamara, D., Sharp, G., Breton, C. V., Schisterman, E., Yeung, E., Mumford, S. L., Fallin, M. D., Lasalle, J. M., Schmidt, R. J., Bakulski, K. M., Annesi-Maesano, I., Heude, B., Nawrot, T. S., Plusquin, M., Ghantous, A., Herceg, Z., Nistico, L., Vafeiadi, M., Kogevinas, M., Vaeaeraesmaeki, M., Kajantie, E., Snieder, H., Corpeleijn, E., Steegers-Theunissen, R. P. M., Yang, I. V., Dabelea, D., Fossati, S., Zenclussen, A. C., Herberth, G., Magnus, M., Haberg, S. E., London, S. J., Munthe-Kaas, M. C., Murphy, S. K., Hoyo, C., Ziegler, A.-G., Hummel, S., Witt, S. H., Streit, F., Frank, J., Raeikkoenen, K., Lahti, J., Huang, R.-c., Almqvist, C., Hivert, M.-F., Jaddoe, V. W. V., Jaervelin, M.-R., Kantomaa, M., Felix, J. F., & Sebert, S. (2023). Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence. MOLECULAR PSYCHIATRY. doi:10.1038/s41380-023-02331-5.


引用: https://hdl.handle.net/21.11116/0000-000E-3F64-C
要旨
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.