The Arabidopsis TIR-NBS-LRR protein CSA1 guards BAK1-BIR3 homeostasis and 
mediates convergence of pattern- and effector-induced immune responses

Schulze, S; Yu, L; Hua, C; Zhang, L; Kolb, D; Ehinger, A; Saile, S; Stahl, M; Franz-Wachtel, M; Li, L; El Kasmi, F; Nuernberger, T; Cevik, V; Kemmerling , P

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The Arabidopsis TIR-NBS-LRR protein CSA1 guards BAK1-BIR3 homeostasis and mediates convergence of pattern- and effector-induced immune responses

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Li, L
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Schulze, S., Yu, L., Hua, C., Zhang, L., Kolb, D., Ehinger, A., Saile, S., Stahl, M., Franz-Wachtel, M., Li, L., El Kasmi, F., Nuernberger, T., Cevik, V., & Kemmerling, P. (2023). The Arabidopsis TIR-NBS-LRR protein CSA1 guards BAK1-BIR3 homeostasis and mediates convergence of pattern- and effector-induced immune responses. Poster presented at Congress of the International Society for Molecular Plant-Microbe Interactions (IS-MPMI 2023), Providence, RI, USA.

引用: https://hdl.handle.net/21.11116/0000-000E-421F-6

要旨

Arabidopsis BAK1/SERK3, a co-receptor of leucine-rich repeat pattern recognition receptors (PRRs), medi- ates pattern-triggered immunity (PTI). Genetic inactivation of BAK1 or BAK1-interacting receptor-like kinases (BIRs) causes cell death, but the direct mechanisms leading to such deregulation remains unclear. Here, we found that the TIR-NBS-LRR protein CONSTITUTIVE SHADE AVOIDANCE 1 (CSA1) physically interacts with BIR3, but not with BAK1. CSA1 mediates cell death in bak1-4 and bak1-4 bir3-2 mutants via components of effector-triggered immunity-(ETI) pathways. Effector HopB1-mediated perturbation of BAK1 also results in CSA1-dependent cell death. Likewise, microbial pattern pg23-induced cell death, but not PTI responses, re- quires CSA1. Thus, we show that CSA1 guards BIR3 BAK1 homeostasis and integrates pattern- and effector- mediated cell death pathways downstream of BAK1. De-repression of CSA1 in the absence of intact BAK1 and BIR3 triggers ETI cell death. This suggests that PTI and ETI pathways are activated downstream of BAK1 for efficient plant immunity.