Lipids glue BAK dimers together

Flores-Romero, Hector; García-Sáez, Ana J.

doi:10.1038/s41594-020-00516-y

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Lipids glue BAK dimers together

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Flores-Romero, H., & García-Sáez, A. J. (2020). Lipids glue BAK dimers together. Nature Structural & Molecular Biology, 27(11), 1003-1004. doi:10.1038/s41594-020-00516-y.

Cite as: https://hdl.handle.net/21.11116/0000-000E-54D6-2

Abstract

BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.