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Journal Article

MIM through MOM: the awakening of Bax and Bak pores

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Cosentino, K., & García-Sáez, A. J. (2018). MIM through MOM: the awakening of Bax and Bak pores. The EMBO Journal, 37(17): e100340. doi:10.15252/embj.2018100340.

Cite as: https://hdl.handle.net/21.11116/0000-000E-6AE2-C
The mechanism whereby mitochondrial DNA (mtDNA) is released into the cytosol and activates the cGAS/STING inflammatory pathway during Bax/Bax‐mediated apoptosis is unknown. In this issue, Riley et al (2018) report that widening of Bax and Bak pores on the mitochondrial outer membrane (MOM) during apoptosis allows the extrusion of the mitochondrial inner membrane (MIM) into the cytosol and its permeabilization to release mtDNA independently of caspases. In this scenario, Bax and Bak emerge as key modulators of the apoptotic immunogenic response.